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Proteomics |
Metaprobes"The metabolic hijackers" |
A |
Affimetrix (Santa Clara, CFA, U.S.A.) |
MassTrace (Woburn, MA) with an agreement with Transcent Therapeutics (Cambridge, MA) |
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Applera, Corp. (formerly PE Corp., Norwalk, CT, U.S.A; Applied Biosystems + Celera Genomics) |
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Applied Molecular Evolution (San Diego,CA, U.S.A.) (Directed Molecular Evolution) |
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Astex Technology (Cambridge, England) (protein - drug complexes) P-commerce |
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Athersis (Cleveland, OH, U.S.A.) - Random A
ctivation of Gene Expression (RAGE
) with application in: functional genomics (protein expression), generation of cell lines expressing validated drug targets, production of known therapeutic proteins, and gene discovery. |
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AxCell Biosciences Corp. (Princeton, NJ): maps for protein interactions AxCell, a subsidiary of Cytogen Corp.,a Princeton
biopharmaceutical company, says its information will help develop more effective medications with fewer side effects ( www.axcellbio.com
). |
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B |
Biacore International(Uppsala, Sveden) |
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Biomolecular Technologies, Inc. (Palo Alto, CA, U.S.A.) |
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C |
Caprion Pharmaceuticals (Montreal, Canada) |
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Chalon Biotech (Toronto, Canada) (high-throughput x-ray crystallographic techniques |
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Ciphergen Biosystems (Palo Alto, CA, U.S.A.) |
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Curagen (New Haven, Conn, U.S.A.) |
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Cytogen Corp. (Princeton, NJ, U.S.A.) |
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E |
ESA Laboratories, Inc. ESAL (Chelmsford, MA, U.S.A.) |
Ecopia BioSciences (Montreal, Canada) |
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G |
Geneva Proteomics (Evanston, IL, U.S.A.) |
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Genomic Solutions, Inc. (Ann Arbor, MI, U.S.A.) |
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Gyros (Uppsala, Sweden) |
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H |
Hybrigenics (Paris, France) |
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I |
Inpharmatica (London, UK) |
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Integrated Genomics, Inc (Chicago, IL, U.S.A.) |
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Intronn LLC (Durham, NC, U.S.A.) |
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Institute for Systems Biology (Seattle, WA, U.S.A.) |
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L |
Large Scale Biology (Vacaville, CA, U.S.A.), with the subsidiary Large Scale Proteomics (Rockville, MD, U.S.A.) "The Human Protein Index" |
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M |
MDS Proteomics (Canada) |
MassTrace (Woburn, MA) with an agreement with Transcent Therapeutics (Cambridge, MA) |
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Micromet (Germany) |
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Myriad Genetics (Salt Lake City, UT, U.S.A.)Myriad Genetics has formed an alliance with Hitachi Ltd. (Tokyo, Japan) and Oracle (Redwood Shores, CA, U.S.A.) to map the
human proteome in less than 3 years. The subsidiary Myriad Proteomics has been created |
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O |
Onyx Pharmaceuticals (Richmond, CA, U.S.A.) |
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Oxford GlycoSciences (Abingdon, UK) and collaboration with Incyte (Palo Alto CA and with Quintiles Transnational (Research Triangle Pasrk, NC)
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P |
Proteom Sciences (Cobham, England) with an agreement with the University of Geneva in Switzerland and with the University of Buckingham (England)
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Proteome Inc. (Beverly, MA, U.S.A.) |
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Proteome Systems Limited (PSL) (Sydney, Australia) |
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S |
Structural GenomiX (San Diego, CA, U.S.A.) (high-throughput x-ray crystallographic techniques) P-Commerce |
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Structure Function Genomics (Princeton, NJ, U.S.A.) (Protein structure) P-commerce |
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Syrrx (LaJolla, CA, U.S.A.) (high-throughput x-ray crystallographic techniques) P-commerce |
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T |
The Proteomic Research Center (made by P.E. Biosystems) (Foster City, CA, U.S.A.) |
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X |
Xerion Pharmaceuticals GmbH (Martinsried b. Munchen, Germany) |
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Xzillion (Frankfurt, Germany) |
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Wilex Biotechnology GmbH (Germany) |
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WITA GmbH (Teltow, Germany ) ( http://www.wita.de ) |
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Note: "P-Commerce" : is referred to companies that are selling information on proteins (= protein information providers) |
MassTrace Inc. and its scientific founders are pioneering the use of enzyme activity (metaprobe) diagnostics in biomedical and nutritional research. Metaprobes give a
quantitative measure of in vivo activity for enzymes that play an important role in disease processes and pharmacological activity. If you know how a given enzyme will act on a given compound, you can design the
compound such that it releases a readily detectable tag in breath or blood plasma. The rate of appearance of the tag gives a direct and quantuitative measurement of the activity of the enzyme.MetaTrace Inc. rdesigns,
produces, and markets proprietary tracer probes which are targeted at specific metabolic processes. Tracer probes are specially formulated organic molecules that incorporate non-radioactive, 13C, 2
H, 15N, and 18O. http://www.dundee.ac.uk/anatphys/wma/masstrace_com_produ ct.htm |
References: "Application of stable isotopes in metabolic research" by: Young, V.R. and Ajami, A.M. (1999): J. Parenteral and Enteral Nutrition
23
(4), 175 - 194 (1999 Jonathan E. Rhades Lecture (The concept of a "gateway" enzyme in a discrete biochemical pathway and how the flow of substrate through this step might be assessed by a "metaprobe" is developed).
Abbreviated bibliography for metaprobes (Bibliography Research) at http://www.masstrace.com/BIBLIO.html
"The Next Wave of the Genomic Business" by Ken Garber (2000), Technology Review 103 (4), 47 - 56]On-line publication "Signals" at:
http://www.signalsmag.com The post genome project: whether the human proteome will be successfully mapped in three years depends on how you define "proteome" by Karen Hopkin (2001),
Scientific American (August issue) Core Proteomics Laboratory at University of Louisville at
http://kdpnw.kdp-baptist.louisville.edu/proteomelab/index.html |
protein structure
Protein structure