"The future will be the study of  the genes and proteins of organisms in the context of their informational pathways or networks."

Leroy Hood

Mapping the genome to cellular function, as an "instantiation problem" (S. Brenner)

The protein trinity:

• ordered
• collapsed -disorder ed
• extended -disorder ed

linking function and disorder (K. Dunker & Z. Obradovic)

Protein splicing

RNA splicing

The Protein folding Puzzle

Each protein strand can fold up into a multitude of conformations

Which of these conformations will have the  desired bio-catalytic activity?

Prion diseases

kinetic barrier associated with misfolding

Nanotech and protein folding

The genetic code is not a synonym for genome sequence

The genotype editing:

1. Gene
2. Genetic material
3. Genome
4. Codome
5. Editome